Apolipoprotein A-I-cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles.
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چکیده
منابع مشابه
Apolipoprotein A-I-cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles.
The ability of lipid-free human apoA-I expressed by transfected Chinese hamster ovary (CHO) cells to form apoA-I-lipid complexes extracellularly when incubated with CHO cell monolayers was investigated. Lipid-free apoA-I was incubated with nontransfected CHO-C19 cells for 24 h and extracellular assembly products were isolated at d < or = 1.235 g/ml; approximately 12% of the incubated apoA-I flo...
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The ability of lipid-free human apoA-I expressed by transfected Chinese hamster ovary (CHO) cells to form apoAI-lipid complexes extracellularly when incubated with CHO cell monolayers was investigated. Lipid-free apoA-I was incubated with nontransfected CHO-CIS cells for 24 h and extracellular assembly products were isolated at d 5 1.235 g/ml; approximately 12% of the incubated apoA-I floated a...
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It is important to understand HDL heterogeneity because various subspecies possess different functionalities. To understand the origins of HDL heterogeneity arising from the existence of particles containing only apoA-I (LpA-I) and particles containing both apoA-I and apoA-II (LpA-I+A-II), we compared the abilities of both proteins to promote ABCA1-mediated efflux of cholesterol from HepG2 cell...
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The principal protein of high density lipoprotein (HDL), apolipoprotein (apo) A-I, in the lipid-free state contains two tertiary structure domains comprising an N-terminal helix bundle and a less organized C-terminal domain. It is not known how the properties of these domains modulate the formation and size distribution of apoA-I-containing nascent HDL particles created by ATP-binding cassette ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1993
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)40758-8